To enable single-key shortcuts, select the Use Single-Key Accelerators To Access Tools option in General preferences.
| Result | Windows/UNIX Action | Mac OS Action |
| Sticky Note tool | S | S |
| Text Edits tool | E | E |
| Stamp tool | K | K |
| Current highlighting tool | U | U |
| Cycle through highlighting tools: Highlighter, Underline Text, Cross Out Text | Shift+U | Shift+U |
| Arrow tool | D | D |
| Cloud tool | Q (Windows only) | Q |
| Text Box tool | X | X |
| Attach file as comment | J | J |
| Cycle through attach tools: Attach File, Record Audio Comment | Shift+J | Shift+J |
| Move focus to comment | Tab | Tab |
| Move focus to next comment | Shift+Tab | Shift+Tab |
| Open pop-up note for comment that has focus | Enter | Return |